解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
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产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It is known that follicle-stimulating hormone (FSH) and insulin stimulate estradiol secretion from cultured non-luteinizing granulosa cells. The interaction between these hormones is less well understood. Granulosa cells from small (2-4 mm) bovine follicles were cultured in serum-free medium to determine if cytochrome...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00218-x
更新日期:2001-06-01 00:00:00
abstract::Human keratinocytes convert 25(OH)D(3) to hormonally active 1alpha,25(OH)(2)D(3) and respond to its antiproliferative/prodifferentiating action in vitro and in vivo. Levels and activity of 1alpha,25(OH)(2)D(3) are short-lived. 1alpha,25(OH)(2)D(3) induces 24-hydroxylase (CYP24) that rapidly metabolizes the hormone, yi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00159-8
更新日期:2001-03-01 00:00:00
abstract::It is well established that 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, plays a role in regulating proliferation and differentiation of cells, in addition to its classic function in mineral homeostasis. Recent studies have also provided evidence for the involvement of 1a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00154-9
更新日期:2001-03-01 00:00:00
abstract::We synthesized various analogues of 1alpha,25-(OH)(2)D(3)-26,23-lactone and examined the effects of them on HL-60 cell differentiation using the evaluation system of the genomic action of 1alpha,25-(OH)(2)D(3). We found that (23S)- and (23R)-25-dehydro-1alpha-OH-D(3)-26,23-lactone (TEI-9647 and TEI-9648) strongly boun...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00146-x
更新日期:2001-03-01 00:00:00
abstract::The conjugation reactions of hydration and dehydrogenation catalyzed by the dehydratase and dehydrogenase activities of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein (DBP) and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase bifunctional protein (LBP) in the side chain degra...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00217-8
更新日期:2001-02-01 00:00:00
abstract::Two-hydroxyestrone (2OHE-1) and 16alpha-hydroxyestrone (16OHE-1) are two estrogen metabolites that may play important roles in the development or promotion of breast cancer. Our study assessed the reliability of a newly developed kit procedure for measuring 2OHE-1. Although under certain conditions the assay would not...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00139-2
更新日期:2001-01-01 00:00:00
abstract::The abundant expression of progesterone receptors (PR) in human meningiomas is well established. It is unknown, however, how PR expression is regulated, especially since estrogen receptors (ER) are virtually absent in these tumors. At the mRNA level, ER splice variants occur in meningioma but these appear not to be in...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(00)00193-8
更新日期:2000-10-01 00:00:00
abstract::Contraceptive methods for breastfeeding women should be safe for the mother and infant and should not interfere with lactation. Progestin-only methods meet these conditions and can be used from the sixth week postpartum. Because all progestins are excreted in milk, those that are insufficiently active by the oral rout...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00125-2
更新日期:2000-10-01 00:00:00
abstract::Trimegestone (TMG) is a novel 19-norpregnane progestin under development for hormone replacement therapy and oral contraception. The objective of the current study was to characterize the potency and steroid receptor selectivity of TMG in several in vitro assays and to compare its activity to that of medroxyprogestero...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00120-3
更新日期:2000-10-01 00:00:00
abstract::The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by LH is the progesterone receptor (PR). Because mice with a mutant PR gene (PRKO) fail to ovulate and are infertile, we have used them as a model in which to determine PR target genes that mig...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00114-8
更新日期:2000-10-01 00:00:00
abstract::Previous studies have demonstrated a persistent rise in serum cortisol concentrations after cardiac surgery. To further investigate this finding and to evaluate the effect of hemodilution that occurs with the onset of cardiopulmonary bypass (CPB), concentrations of cortisol-binding globulin (CBG), total and unbound co...
journal_title:Steroids
pub_type: 临床试验,杂志文章
doi:10.1016/s0039-128x(00)00133-1
更新日期:2000-09-01 00:00:00
abstract::We describe a convenient and stereoselective route to the synthesis of 27-hydroxycholesterol. Also its radiolabeled analog, 22, 23 di [(3)H]-27-hydroxycholesterol with high specific radioactivity (55 Ci/mmol) was synthesized by this method. Julia condensation of steroidal 22-sulfone with aldehyde, led to the addition ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00099-4
更新日期:2000-07-01 00:00:00
abstract::A series of chemiluminescent 17beta-estradiol probes were synthesized. Relative equilibrium dissociation constants (K(D)) for the interaction of an anti-E(2) Fab fragment for the probes in solution were evaluated using a single E(2)-analog biosensor surface on a BIAcore surface plasmon resonance instrument. The result...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00091-x
更新日期:2000-06-01 00:00:00
abstract::The characterization of new conjugated vitamin D metabolites in rat bile was performed using HPLC, liquid chromatography/tandem mass spectrometry combined derivatization, and GC-MS. After the administration of 24,25-dihydroxyvitamin D(3) to rats, 23, 25-dihydroxy-24-oxovitamin D(3) 23-glucuronide, 3-epi-24, 25-dihydro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00087-8
更新日期:2000-05-01 00:00:00
abstract::Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeri...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00108-7
更新日期:2000-04-01 00:00:00
abstract::7-Oxo-dehydroepiandrosterone, which can be formed from dehydroepiandrosterone (DHEA) by several mammalian tissues, is more effective than its parent steroid as an inducer of thermogenic enzymes when administered to rats. Using the Morris water maze procedure, we tested DHEA and its 7-oxo-derivative for their ability t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00094-x
更新日期:2000-03-01 00:00:00
abstract::This study describes a new approach using stable isotope methodology in evaluating 11beta-HSD activities in vivo based on urinary excretion of cortisol, cortisone, and their A-ring reduced metabolites. The method involved the measurement of deuterium-labeled cortisol and its deuterium-labeled metabolites by GC/MS simu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00086-0
更新日期:2000-02-01 00:00:00
abstract::Evaluation of sex steroids in cervical mucus was performed at different phases of spontaneous or clomiphene-citrate-induced ovulatory cycles. To this end, 11 women with normal ovulatory cycles and 9 subjects with polycystic ovary syndrome of comparable age and body mass index were investigated. Serum and cervical mucu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00074-4
更新日期:2000-01-01 00:00:00
abstract::2,2,6,6-Tetramethyl piperidine-N-oxyl nitroxyls are known to partition between aqueous and lipid phases, thus serving as probes to study membrane dynamics. The synthesis of a novel steroidal spin label, 3alpha-hydroxycholan-24-yl-(2",2",6",6"-tetramethyl-N-oxyl)p iperidyl butan-1',4'-dioate, containing 2,2,6,6-tetrame...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00072-0
更新日期:1999-12-01 00:00:00
abstract::Glucuronidation of 24,25-dihydroxyvitamin D3 has been investigated in in vitro and in vivo experiments. Three positional isomers of 24,25-dihydroxyvitamin D3 monoglucuronide were synthesized from 24,25-dihydroxyprovitamin D3 derivatives with Koenigs-Knorr reaction and used as standard samples. In the presence of the r...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00057-4
更新日期:1999-10-01 00:00:00
abstract::This study examined the role of protein kinase C enzymatic activity as a physiologic determinant of stromal cell death in decidua basalis (DB) during pregnancy. The expression of epidermal growth factor receptor (EGF-R) and Bcl2 was used as an indicator of stromal cell proliferation/survival, whereas Bax and the occur...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00044-6
更新日期:1999-09-01 00:00:00
abstract::Apoptosis is a highly organized mechanism that allows specific cells to die in a controlled manner. Apoptosis can be induced by a variety of agents in a great number of cell types, but cell shrinkage and discrete chromatin cleavage remain common components of apoptosis that is manifested by constitutive enzymes. Despi...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(99)00034-3
更新日期:1999-09-01 00:00:00
abstract::Chick kidney and brain were analyzed for the subcellular distribution (if any) of a putative plasma membrane receptor for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Fractionation protocols were found to be based not only on differential centrifugation conditions, but also gentleness of resuspension procedures, and suffic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00030-6
更新日期:1999-08-01 00:00:00
abstract::Smith-Lemli-Opitz syndrome (SLOS) is a malformation syndrome associated with 7-dehydrocholesterol (7DHC) 7-reductase deficiency. Although SLOS can be detected in an affected fetus before midpregnancy by measurement of 7DHC levels in amniotic fluid or chorionic villus cells, a noninvasive, more routine method is needed...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00026-4
更新日期:1999-07-01 00:00:00
abstract::Over the past 30 years, numerous studies in invertebrates and vertebrates have established a role of calcium in oocyte maturation as well as in the resumption and progression of follicular development. Polycystic ovarian syndrome (PCO) is characterized by hyperandrogenic chronic anovulation, theca cell hyperplasia, an...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00012-4
更新日期:1999-06-01 00:00:00
abstract::The functions of the group of proteins known as nuclear receptors will be understood fully only when their working three-dimensional structures are known. These ligand-activated transcription factors belong to the steroid-thyroid-retinoid receptor superfamily, which include the receptors for steroids, thyroid hormone,...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(99)00014-8
更新日期:1999-05-01 00:00:00
abstract::The condensation of O-substituted hydroxylamines with conjugated 3-oxo-4-en steroids results in a mixture of syn-anti configurations. Syn-anti ratios are influenced by sterical hindrance between the oximino substituents (e.g. O-benzyl) and the steroidal skeleton. Stereostructures and isomeric ratios were proved by det...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00111-1
更新日期:1999-04-01 00:00:00
abstract::We have previously shown that the photoactive 4-azasteroid, [1,2 3H]N-4(benzylbenzoyl)-3-oxo-4-aza-4-methyl-5alpha-androst an-17beta-carboxamide is an effective probe of rat steroid 5alpha-reductase (isozyme-1) (5alphaR-1). In the current investigation, PEG-fractionated (6.5%) detergent-solubilized preparations contai...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00087-7
更新日期:1999-03-01 00:00:00
abstract::The hormone 1alpha,25(OH)2vitamin D3 (1,25-D) produces biological responses via both genomic and rapid mechanisms. The genomic responses are linked to a nuclear receptor, while the rapid responses are believed to utilize other signal transduction pathways that are likely linked to a putative cell membrane receptor for...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(98)00091-9
更新日期:1999-01-01 00:00:00
abstract::Estrogen is an important atheroprotective molecule that causes the rapid dilation of blood vessels by stimulating endothelial nitric oxide synthase (eNOS). There is also evidence that estrogen modulates airway epithelial NO production, thereby potentially affecting bronchial hyperresponsiveness. Studies in cultured en...
journal_title:Steroids
pub_type:
doi:10.1016/s0039-128x(98)00105-6
更新日期:1999-01-01 00:00:00
abstract::Using 1 alpha,2 alpha-oxido-cholesta-5,7-diene-3 beta,25-diol (2) as a starting material, the provitamins of calcitriol with an additional 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-substituent (3,4,5) are obtained by transdiaxial opening of the oxirane ring with nucleophiles. An efficient irradiation process ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00072-5
更新日期:1998-12-01 00:00:00
abstract::26,26,26,27,27,27-Hexafluo-1,25(OH)2 vitamin D3, the hexafluorinated analog of 1,25(OH)2 vitamin D3, has been reported to be several times more potent than the parent compound regarding some vitamin D actions. The reason for enhanced biologic activity in the kidneys and small intestine appears to be related to F6-1,25...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00055-5
更新日期:1998-10-01 00:00:00
abstract::Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than estrogen levels in plasma, presumably due to in situ formation of estrogen. The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Thus, inhibitors...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00044-0
更新日期:1998-07-01 00:00:00
abstract::Glucocorticoids are well-recognized modulators of immunocytes and osteoblasts via specific receptor-mediated mechanisms. We have evaluated the in vitro effect of interleukin 2 (IL-2) on the expression of glucocorticoid receptors (GRs) in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors and osteo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00023-3
更新日期:1998-05-01 00:00:00
abstract::During the second half of the luteal phase, the human corpus luteum becomes responsive to regular luteinizing hormone (LH) pulses. These LH pulses stimulate progesterone secretion tonically, and during this tonic stimulation, additional LH-independent progesterone pulses occur, which are particularly pronounced in wom...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(98)00037-3
更新日期:1998-05-01 00:00:00
abstract::There is considerable evidence that although estradiol may trigger the preovulatory surge of gonadotropins, progesterone is required for its full magnitude and duration and that glucocorticoids bring about selective follicle-stimulating hormone release. The luteinizing hormone-releasing hormone (LHRH) neuron does not ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(98)00031-2
更新日期:1998-05-01 00:00:00
abstract::These studies investigated whether treatment with carbenoxolone (CBX), an inhibitor of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), resulted in an enhanced mineralocorticoid response to endogenous or infused cortisol. In conscious sodium replete sheep with a parotid fistula, infusion of CBX (40 mg/h for 10 days...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00141-4
更新日期:1998-02-01 00:00:00
abstract::The isoflavonoids, genistein (4',5,7-trihydroxyisoflavone), biochanin A (5,7-dihydroxy-4'-methoxyisoflavone), daidzein (4',7-dihydroxyisoflavone), and formononetin (7-hydroxy-4'-methoxyisoflavone) are supposed to be health-promoting dietary factors of plant origin. They are particularly abundant in seeds and other par...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00104-9
更新日期:1998-01-01 00:00:00
abstract::In this paper, we studied the effect of heme availability on corticosterone and aldosterone synthesis in rat adrenal. We found that hemin stimulated corticosterone and aldosterone production in adrenal homogenates in a dose-dependent fashion. Hemin administration to rats also provoked an increase in both corticosteron...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00074-3
更新日期:1997-12-01 00:00:00
abstract::The synthesis of delta 7,9(11)-lanostadiene derivatives functionalized at C(32) starting from 3 beta-acetoxy-7 alpha,32-epoxylanostan-11-one has been presented. The delta 7,9(11) moiety was efficiently introduced in three steps in 71% yield by the regioselective abstraction of allylic 8 beta hydrogen. The formyl group...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(97)00075-5
更新日期:1997-11-01 00:00:00